When the SIRUM box or mailer is full, just put on the prepaid shipping label that we sent you after registration and let us know that the donation is ready. We will schedule a courier pick-up for the next day. Medicine is sent directly to the recipients; donors and recipients can track the progress of the shipment online and with email notifications. We can also provide any shipping supplies you may need including boxes (for large donations), padded mailers (for small donations), and packing tape.